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#1
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"Capt. Rob" wrote:
If Robbie did buy the boat, the small holding tank will keep him company, he won't be the only one full of ****. Why would I use a holding tank? Why indeed? Unless you untie you can use the club facilities and save the pump-out fee. Cheers Martin ------------ And now a word from our sponsor ---------------------- For a quality mail server, try SurgeMail, easy to install, fast, efficient and reliable. Run a million users on a standard PC running NT or Unix without running out of power, use the best! ---- See http://netwinsite.com/sponsor/sponsor_surgemail.htm ---- |
#2
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Why indeed? Unless you untie you can use the club facilities and save
the pump-out fee. Why would I use the club facilities when I have a perfectly fine and legal system on board with no holding tank required? RB |
#3
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"Capt. Rob" wrote:
Why indeed? Unless you untie you can use the club facilities and save the pump-out fee. Why would I use the club facilities when I have a perfectly fine and legal system on board with no holding tank required? Sorry, I didn't realize that your colon had become that enlarged! Cheers Martin RB ------------ And now a word from our sponsor --------------------- For a secure high performance FTP using SSL/TLS encryption upgrade to SurgeFTP ---- See http://netwinsite.com/sponsor/sponsor_surgeftp.htm ---- |
#4
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Sorry, I didn't realize that your colon had become that enlarged!
I don't have a colon. Am homebound disabled. RB |
#5
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What happened to your colon?
"Capt. Rob" wrote in message ups.com... Sorry, I didn't realize that your colon had become that enlarged! I don't have a colon. Am homebound disabled. RB |
#6
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He ate it.
"Bob Crantz" wrote in message k.net... What happened to your colon? "Capt. Rob" wrote in message ups.com... Sorry, I didn't realize that your colon had become that enlarged! I don't have a colon. Am homebound disabled. RB |
#7
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Did you have Crohn's disease?
"Capt. Rob" wrote in message ups.com... Sorry, I didn't realize that your colon had become that enlarged! I don't have a colon. Am homebound disabled. RB |
#8
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Did you have Crohn's disease?
No, but Crohn's killed my mother. I have something more mild and have been in remission since Thomas was born. RB |
#9
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I'm sorry to hear that. I hope your case stays in remission. Does stress
cause it to flare up? "Capt. Rob" wrote in message ps.com... Did you have Crohn's disease? No, but Crohn's killed my mother. I have something more mild and have been in remission since Thomas was born. RB |
#10
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Ulcerative colitis (UC), a chronic inflammatory condition associated with a
predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation. A longstanding question in cancer research is the strong association between certain chronic inflammatory conditions and the concomitant elevated risk for malignancy in affected tissues. Understanding the molecular mechanisms driving the progression to cancer may not only provide more effective means of prevention but also shed light on mechanisms of carcinogenesis. Ulcerative colitis (UC), which affects as many as 6 per 100,000 people in the United States, is a relapsing form of chronic inflammatory disease of the large bowel. Patients with more than a 10-year history of disease have a 20- to 30-fold greater risk of developing colorectal cancer (1). Both chromosomal instability (CI) and microsatellite (short, repetitive nucleotide sequences in DNA) instability (MSI) are present in UC and can be detected early in dysplastic, premalignant tissues (2, 3). What are the sources of these changes in DNA sequence? Chromosomal changes are frequent in cancer and MSI has been clearly documented as a result of mutations in mismatch repair enzymes in the hereditary nonpolyposis colon cancer syndrome. MSI is also observed in many other malignancies (4). Accumulation of mutations in microsatellites could be the result of alterations in enzymes that normally guarantee DNA stability, thus leading to a mutator phenotype (4). Existing hypotheses postulate that excess amounts of free radicals found in inflamed UC tissues overwhelm DNA repair pathways, leading to the accumulation of damaged DNA (5), or that mismatch repair pathways are inactivated, either directly by oxidative stress (6) or by hypermethylation (7). In the traditional view, members of DNA repair pathways are heroic players, stoically laboring against the overwhelming tide of genetic insults thrown their way. "Capt. Rob" wrote in message ps.com... Did you have Crohn's disease? No, but Crohn's killed my mother. I have something more mild and have been in remission since Thomas was born. RB |
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