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In article .net,
Bob Crantz wrote: Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation. This is a pretty serious disease. A friend of mine almost died from it. They had to remove most of his colon to save his life. -- "j" ganz @@ www.sailnow.com |