Did you have Crohn's disease?


No, but Crohn's killed my mother. I have something more mild and have
been in remission since Thomas was born.

RB

I'm sorry to hear that. I hope your case stays in remission. Does stress
cause it to flare up?



"Capt. Rob" wrote in message
ps.com...
Did you have Crohn's disease?


No, but Crohn's killed my mother. I have something more mild and have
been in remission since Thomas was born.

RB

Ulcerative colitis (UC), a chronic inflammatory condition associated with a
predisposition to colon cancer, is frequently characterized by DNA damage in
the form of microsatellite instability (MSI). A new report links
inflammation in UC with increases in the DNA repair enzymes 3-methyladenine
DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically,
with increased MSI. These findings may represent a novel mechanism
contributing to MSI in chronic inflammation.


A longstanding question in cancer research is the strong association between
certain chronic inflammatory conditions and the concomitant elevated risk
for malignancy in affected tissues. Understanding the molecular mechanisms
driving the progression to cancer may not only provide more effective means
of prevention but also shed light on mechanisms of carcinogenesis.
Ulcerative colitis (UC), which affects as many as 6 per 100,000 people in
the United States, is a relapsing form of chronic inflammatory disease of
the large bowel. Patients with more than a 10-year history of disease have a
20- to 30-fold greater risk of developing colorectal cancer (1). Both
chromosomal instability (CI) and microsatellite (short, repetitive
nucleotide sequences in DNA) instability (MSI) are present in UC and can be
detected early in dysplastic, premalignant tissues (2, 3). What are the
sources of these changes in DNA sequence? Chromosomal changes are frequent
in cancer and MSI has been clearly documented as a result of mutations in
mismatch repair enzymes in the hereditary nonpolyposis colon cancer
syndrome. MSI is also observed in many other malignancies (4). Accumulation
of mutations in microsatellites could be the result of alterations in
enzymes that normally guarantee DNA stability, thus leading to a mutator
phenotype (4). Existing hypotheses postulate that excess amounts of free
radicals found in inflamed UC tissues overwhelm DNA repair pathways, leading
to the accumulation of damaged DNA (5), or that mismatch repair pathways are
inactivated, either directly by oxidative stress (6) or by hypermethylation
(7). In the traditional view, members of DNA repair pathways are heroic
players, stoically laboring against the overwhelming tide of genetic insults
thrown their way.

"Capt. Rob" wrote in message
ps.com...
Did you have Crohn's disease?


No, but Crohn's killed my mother. I have something more mild and have
been in remission since Thomas was born.

RB

In article .net,
Bob Crantz wrote:
Ulcerative colitis (UC), a chronic inflammatory condition associated with a
predisposition to colon cancer, is frequently characterized by DNA damage in
the form of microsatellite instability (MSI). A new report links
inflammation in UC with increases in the DNA repair enzymes 3-methyladenine
DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically,
with increased MSI. These findings may represent a novel mechanism
contributing to MSI in chronic inflammation.

This is a pretty serious disease. A friend of mine almost died from
it. They had to remove most of his colon to save his life.

--
"j" ganz @@
www.sailnow.com

This is a pretty serious disease. A friend of mine almost died from
it. They had to remove most of his colon to save his life.


Well in my case I never required the surgery. But it knocked me out for
quite a few years and for a while I wondered how much more I could
take. Still, I kept sailing, got married, had a son...and now I'm in
remission. I think it took the power of all three and a lot of effort
to do it or maybe I was just lucky. No sign of UC in my colon on my
last checkup and now I'm buying a hell of a nice boat.

RB
Beneteau First 35s5
NY

In article .com,
Capt. Rob wrote:
This is a pretty serious disease. A friend of mine almost died from
it. They had to remove most of his colon to save his life.


Well in my case I never required the surgery. But it knocked me out for
quite a few years and for a while I wondered how much more I could
take. Still, I kept sailing, got married, had a son...and now I'm in
remission. I think it took the power of all three and a lot of effort
to do it or maybe I was just lucky. No sign of UC in my colon on my
last checkup and now I'm buying a hell of a nice boat.

My friend had numerous surgeries. He went from 205 lbs. down to
135. Now, he's back to a normal weight.



--
"j" ganz @@
www.sailnow.com

You just said: you had no colon; now you say: you do.

What you are doing is really bad Karma.

Why not tell the truth for once? I was actually going to get the
Congregation to pray for you.

Shame on you!

"Capt. Rob" wrote in message
oups.com...
This is a pretty serious disease. A friend of mine almost died from
it. They had to remove most of his colon to save his life.


Well in my case I never required the surgery. But it knocked me out for
quite a few years and for a while I wondered how much more I could
take. Still, I kept sailing, got married, had a son...and now I'm in
remission. I think it took the power of all three and a lot of effort
to do it or maybe I was just lucky. No sign of UC in my colon on my
last checkup and now I'm buying a hell of a nice boat.

RB
Beneteau First 35s5
NY

Sexually transmitted diseases of the colon, rectum, and anus. The challenge
of the nineties.

Wexner SD.

Department of Colorectal Surgery, Cleveland Clinic Florida, Fort Lauderdale.

During the past two decades, an explosive growth in both the prevalence and
types of sexually transmitted diseases has occurred. Up to 55 percent of
homosexual men with anorectal complaints have gonorrhea; 80 percent of the
patients with syphilis are homosexuals. Chlamydia is found in 15 percent of
asymptomatic homosexual men, and up to one third of homosexuals have active
anorectal herpes simplex virus. In addition, a host of parasites, bacterial,
viral, and protozoan are all rampant in the homosexual population.
Furthermore, the global epidemic of AIDS has produced a plethora of
colorectal manifestations. Acute cytomegalovirus ileocolitis is the most
common indication for emergency abdominal surgery in the homosexual AIDS
population. Along with cryptosporidia and isospora, the patient may present
to the colorectal surgeon with bloody diarrhea and weight loss before the
diagnosis of human immunodeficiency virus (HIV) disease. Other patients may
present with colorectal Kaposi's sarcoma or anorectal lymphoma, and
consequently will be found to have seropositivity for HIV. However, in
addition to these protean manifestations, one third of patients with AIDS
consult the colorectal surgeon with either condylomata acuminata, anorectal
sepsis, or proctitis before the diagnosis of HIV disease. Although
aggressive anorectal surgery is associated with reasonable surgical results
in some asymptomatic HIV positive patients, the same procedures in AIDS
(symptomatic HIV positive) patients will often be met with disastrous
results. It is incumbent upon the surgeon, therefore, to recognize the
manifestations of HIV disease and diagnose these conditions accordingly.




"Capt. Rob" wrote in message
oups.com...
This is a pretty serious disease. A friend of mine almost died from
it. They had to remove most of his colon to save his life.


Well in my case I never required the surgery. But it knocked me out for
quite a few years and for a while I wondered how much more I could
take. Still, I kept sailing, got married, had a son...and now I'm in
remission. I think it took the power of all three and a lot of effort
to do it or maybe I was just lucky. No sign of UC in my colon on my
last checkup and now I'm buying a hell of a nice boat.

RB
Beneteau First 35s5
NY

Bob Crantz wrote:

Sexually transmitted diseases of the colon, rectum, and anus. The challenge
of the nineties.

{snipped sordid medical details}

You have way to much free time on your hands Glen.

Cheers
Martin