The basic route is through LIS, to Buzzard's Bay, Mass, through the canal at
the top of Buzzard's Bay, and then across Massachusetts Bay to P-town.

There are so many stopping points in LIS and Buzzard's Bay, you can almost wing
it, as long as you have a good VHF and info on marinas and anchorages.

But you do need to plan your canal transit and the Mass bay transit with tides
and time in mind, as there is less flexibility in that part of the journey.