Assuming that transmission is not an issue -
are there any "hull-issues" that should imply that a given hull simply "runs
better" with a LH instead of a RH - or vice versa?

Anders
Denmark

I've lost track of the boat in question. The issue could well involve
"operator" ease or senses such as the steering station location to the side,
which can be a factor when docking.
Some people just have a "feel" that a particular rotation works better or feels
better to them